Most Soma categories make heavy use of RNG manipulation sequences (commonly called "manips") to guarantee that specific certain items or souls always drop from certain specific enemies. This allows runners speedrunners to utilize routes which would otherwise require impossibly low drop odds to succeed.

Whenever a new game is started or a save file is loaded, the RNG seed will always be reset to the same value. From that pointDepending on the room Soma loads into, a runner can it is sometimes possible for the player to perform standardized movements and actions which deterministically to advance the RNG deterministically, until it reaches a value to one that which produces the a desired dropfrom a specific enemy.